海量資源，盡在掌握
‘Adrugisnotadrug’because,whenadministeredtoahumanbeing,inthegeneralcase,itcontains:●Activecompoundatadosewithinalimitedrange,sometimesasaracemicmixture.●Manufacturingimpurities.●Oneormoreexcipients.●Degradantsoftheactivecompound.●Degradantsoftheimpurities...[繼續(xù)閱讀]
Thepresentthemeissue,whichhighlightsthepharmaceuticalperspectiveonpolymorphism,followsanearlierthemeissueon“CharacterizationoftheSolidState”,whichhighlightsthefundamentalaspectsofthisphenomenon.Currentresearchareasofgreatestfundamentalinterestare:(a)deter...[繼續(xù)閱讀]
Pharmaceuticsisamultidisciplinaryappliedscienceconcernedwithdeliveringandmaintainingappropriatedrugconcentrationsattargetsitesinthebodyforappropriatetimes,thusalleviatingdiseasebyoptimizingdrugeffectsovertime.Itincludesdrugproducttechnology,biopharmaceuti...[繼續(xù)閱讀]
Recentadvancesinpulmonarydrugdelivery,stimulatedbythe“phase-out”ofchlorofluorocarbon(CFC)propellantsinpressurizedinhalerstogetherwiththedesiretousethelungsasaportaltothesystemiccirculation,haveresultedinsignificantinterestinthistechnology.Theresearchiscon...[繼續(xù)閱讀]
Aabsolutebioavailability絕對(duì)生物利用度absorbance吸收率adhesive帶粘性的,膠粘;粘合劑aerosol浮質(zhì)(氣體中的懸浮微粒,如煙、霧等);[化]氣溶膠,氣霧劑,煙霧劑amorphous無(wú)定形的,無(wú)組織的amphiphilicagent兩親劑ampule一次用量的針劑;安瓿(=ampoule)antifoa...[繼續(xù)閱讀]
Proteinsaretheagentsofbiologicalfunction.Virtuallyeverycellularactivityisdependentononeormoreparticularproteins.Thus,aconvenientwaytoclassifytheenormousnumberofproteinsisbythebiologicalrolestheyfill.EnzymesByfarthelargestclassofproteinsisenzymes.Morethan3...[繼續(xù)閱讀]
First,biochemistryisanintrinsicallybeautifulandfascinatingbodyofknowledge.Wenowknowtheessenceandmanyofthedetailsofthemostfundamentalprocessesinbiochemistry,suchashowasinglemoleculeofDNAreplicatestogeneratetwoidenticalcopiesofitselfandhowthesequenceofbases...[繼續(xù)閱讀]
GenesCodeforParticularProteinsThefirstscientisttoinvestigatethequestionofhowgenesaffectphenotypewasSirArchibaldGarrod,whosestudiesofalkaponuriaimpliedarelationshipbetweengenesandenzymes.ThirtyyearslaterBeadleandEphrussishowedarelationshipbetweenparticular...[繼續(xù)閱讀]
Oneimportantapplicationofgenomicsisthediscoveryofthelevelsofallthegenesinanorganismatanyonetime,usingDNAchipsorsimilartoolsthatmeasurelevelsofmRNAs.Thiskindoffunctionalgenomicsstrategyusuallyfocusesonthegenetranscriptsinacellatagiventime.Ifweweretoconside...[繼續(xù)閱讀]
DespitecontinuingpovertyinmanypartsoftheworldandthedevastatingeffectsofHIVandAIDSinfectionontheAfricancontinentandelsewhere,thehealthoftheworld’spopulationisprogressivelyimproving.Thisisreflectedintheincreaseinlifeexpectancythathasbeenrecordedforthegreatm...[繼續(xù)閱讀]
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